H. Andy Zhong, Ph.D.
- Ralph Wardle Diamond Professor, Interim Department Chair
- DSC 338
- Organic, Medicinal, and Computational Chemistry
Additional Information
Awards and Honors
Excellence in Research/Creative Activity Award, College of Arts and Sciences, University of Nebraska at 51社区, (2020).
The Cottrell College Science Award, Research Corporation (2008)
Editorial Service:
Editorial Board, Journal of Molecular Graphics & Modelling (2020-present)
Associate Editor, Journal of Molecular Graphics & Modelling (2024-present)
Review Board Member, Cancers (2020-present)
Guest Editor, Special Issue: Structure-based Design on Anticancer Drug Discovery. Current Topics in Medicinal Chemistry, 2020, Vol. 20, Issue 10.
Co-Guest Editor (with Guest Editor, J. Phillip Bowen), Special Issue: Advances in Drug Discovery for the Treatment of Cancer: Many Approaches, One Goal, Current Topics in Medicinal Chemistry, 2016, Vol. 16 (13).
Guest Editor, Special Issue: ADME and Toxicity in Early Drug Discovery, Current Topics in Medicinal Chemistry, 2013, Vol. 13 (11).
Publications
For a complete publication list. please . (Google Scholar h-index: 27)
- Expert Opinion on Therapeutic Patents, 2024, 34(3), 141-158. DOI:
- , Expert Opinion on Therapeutic Patents, 2024, 34(1-2), 51-69, DOI: HA.*
- Zhong, H.A.*; Goodwin, D.T. . Molecules 2024, 29, 1233. https://doi.org/10.3390/molecules29061233
- Hamilton LJ, Pattabiraman M, Zhong HA, Walker M, Vaughn H, Chandra S. . Pharmaceuticals. 2023, 16(7), 917; https://doi.org/10.3390/ph16070917.
- J. Mol. Graphics & Modeling., 2023, 121, 108433.
- Bioorg Med Chem. 2021, 46:116368 . https://doi.org/10.1016/j.bmc.2021.116368
- Dima A. Sabbah, Rima Hajjo, Sanaa K. Bardaweel & Haizhen A. Zhong.* , Expert Opinion on Therapeutic Patents, 2021, 31:10, 877-892, DOI:
10.1080/13543776.2021.1924150. - Sabbah DA, Hajjo R, Bardaweel SK, Zhong HA. . Curr Top Med Chem. 2021;21(7):571-596. doi: 10.2174/1568026621666210119111409. PMID: 33463470.
- Hamilton LJ, Walker M, Pattabiraman M, Zhong HA, Luedtke B, Chandra S. . Pharmacol Res. 2021 Mar;165:105410. doi: 10.1016/j.phrs.2020.105410. Epub 2021 Jan 2. PMID: 33401004.
- Sabbah DA, Hajjo R, Bardaweel SK, Zhong HA. . Curr Top Med Chem. 2021; 21(6):442-460. doi: 10.2174/1568026620666201207095117. PMID: 33292134.
- Sabbah DA, Hajjo R, Sweidan K, Zhong HA. . Curr Comput Aided Drug Des. 2020 Aug 19. doi: 10.2174/1573409916666200819113444. Epub ahead of print. PMID: 32814537.
- Curr Top Med Chem. 2020; 20 (10) :813-814. doi: 10.2174/156802662010200331100200. PubMed PMID: 32463006.
- Assay Drug Dev Technol. 2020 Apr; 18 (3) :109-118. doi: 10.1089/adt.2019.965. PubMed PMID: 32319818.
- Bioorg Med Chem. 2020 Apr 1; 28 (7) :115395. doi: 10.1016/j.bmc.2020.115395. Epub 2020 Feb 18. PubMed PMID: 32113844
- Almahmoud S, Zhong HA. . Int. J. Mol. Sci., 2019, 20, 4654. doi:10.3390/ijms20184654.
- Daszynski DM, Santhoshkumar P, Phadte AS, Sharma KK, Zhong HA, Lou MF, Kador PF. . Sci Rep. 2019 Jun 11; 9(1):8459. doi: 10.1038/s41598-019-44676-4.
- Almahmoud S, Wang X, Vennerstrom JL, Zhong HA*. . Molecules. 2019 Jun 7;24(11). pii: E2159. doi: 10.3390/molecules24112159.
- Sabbah DA, Ibrahim AH, Talib WH, Alqaisi KM, Sweidan K, Bardaweel SK, Sheikha GA, Zhong HA, Al-Shalabi E, Khalaf RA, Mubarak MS. . Med Chem. 2019, 15, 417-429. doi: 10.2174/1573406414666180912111846.
- Zhong HA, Santos EM, Vasileiou C, Zheng Z, Geiger JH, Borhan B, Merz KM Jr. . J Am Chem Soc. 2018 Mar 14;140(10):3483-3486. doi: 10.1021/jacs.7b10368. Epub 2018 Feb 28..
- Xianting Cao, Haizhen A. Zhong, Pengfei Zhang, and Hui Zheng. . Journal of CO2 Utilization, 2018, 24, 250-255.
- Sabbah DA, Al-Tarawneh F, Talib W, Sweidan K, Bardaweel S, Al-Shalabi E, Zhong HA, Abu Sheikha G, Abu Khalaf R, Mubarak MS. . Medicinal Chemistry. 2018, 14 (7), 695-708; doi: 10.2174/1573406414666180412160142.
- Sabbah DA, Hishmah B, Sweidan K, Bardaweel S, AlDamen M, Zhong HA, Abu Khalaf R, Ibrahim AH, Al-Qirim T, Abu Sheikha G, Mubarak MS. . Anticancer Agents Med Chem. 2018, 18(2), 263-276. doi: 10.2174/1871520617666170911171152.
- Kumar V, Chaudhary AK, Dong Y, Zhong HA, Mondal G, Lin F, Kumar V, Mahato RI. . Sci Rep. 2017 May 10; 7(1):1665. doi: 10.1038/s41598-017-01942-7.
- Udumula V, Endres JL, Harper CN, Jaramillo L, Zhong HA, Bayles KW, Conda-Sheridan M. . Eur J Med Chem. 2017, 125:710-721. doi: 10.1016/j.ejmech.2016.09.079. Epub 2016 Sep 28.
- Sabbah DA, and Zhong HA. . J. Mol. Graphics & Modeling., 2016, 68, 206-215
- Sabbah DA, Hu J, Zhong HA. . Curr. Top. Med. Chem., 2016, 16, 1413-26.
- Xu D, Li R, Wu J, Jiang L, Zhong HA. . Curr. Top. Med. Chem., 2016, 16, 1441-51.
- Ehlers T, Furness S, Robinson TP, Zhong HA, Goldsmith D, Arbiser J, Bowen JP. . Curr. Top. Med. Chem. , 2016, 16 (13), 1478-88.
- Curr Top Med Chem. 2016;16(13):1411-2. doi: 10.2174/1568026616999151012120106.
- Curr Top Med Chem. 2016;16(9):897-8. doi: 10.2174/1568026616999151029114013.
- Infect Genet Evol. 2014 Mar;22:192-200. doi: 10.1016/j.meegid.2013.10.011.
- Curr Top Med Chem. 2013;13(11):1255-6. doi: 10.2174/15680266113139990031
- Curr Pharm Des. 2013;19(26):4701-13. doi: 10.2174/1381612811319260004.
- Synthesis and self-assembly of triphenylene-containing conjugated macrocycles. RSC advances. 2013; 3:6008. doi: DOI: 10.1039/C3RA23421E.
- Curr Top Med Chem. 2013;13(11):1290-307. doi: 10.2174/15680266113139990034.
- J Chem Inf Model. 2012 Dec 21;52(12):3213-24. doi: 10.1021/ci3003057.
- Bioorg Med Chem. 2012 Dec 15;20(24):7175-83. doi: 10.1016/j.bmc.2012.09.059.
- PLoS One. 2012;7(7):e38665. doi: 10.1371/journal.pone.0038665
- Bioorg Med Chem Lett. 2012 Jan 15;22(2):876-80. doi: 10.1016/j.bmcl.2011.12.044.
- Int J Bioinform Res Appl. 2012;8(1-2):81-98. doi: 10.1504/IJBRA.2012.045978.
- Synthesis and optical properties of perylene diimide derivatives with triphenylene-based dendrons linked at the bay positions through a conjugated ethynyl linkage. Tetrahedron. 2012; 68(13):2806. doi: .
- ACS Med Chem Lett. 2011 Jun 9;2(6):455-60. doi: 10.1021/ml200031m.
- J Phys Chem A. 2011 Mar 10;115(9):1579-92. doi: 10.1021/jp1085334.
- Curr Top Med Chem. 2011;11(12):1571-90. doi: 10.2174/156802611795860924
- Curr Med Chem. 2011;18(36):5528-44. doi: 10.2174/092986711798347298.
- J Chem Inf Model. 2010 Oct 25;50(10):1887-98. doi: 10.1021/ci1002679.
- J Mol Graph Model. 2009 Nov;28(4):336-46. doi: 10.1016/j.jmgm.2009.08.012.
- Bioorg Med Chem Lett. 2008 Jan 15;18(2):542-5. doi: 10.1016/j.bmcl.2007.11.090
- J Am Chem Soc. 2007 Oct 24;129(42):12809-14. doi: 10.1021/ja073687x.
- Galahad, Tripos Inc. (Computer Software Review). J. Am. Chem. Soc.. 2007; 129:5780. doi: DOI: 10.1021/ja069815j
- Curr Top Med Chem. 2007;7(14):1379-93. doi: 10.2174/156802607781696855.
- J Chem Theory Comput. 2006 Mar;2(2):342-53. doi: 10.1021/ct050182t
- Curr Med Chem. 2006;13(8):849-62. doi: 10.2174/092986706776361085
- J Mol Graph Model. 2005 Sep;24(1):1-9. doi: 10.1016/j.jmgm.2005.04.003
- J Chem Theory Comput. 2005 Mar;1(2):230-8. doi: 10.1021/ct049890p
- Proteins. 2005 Jan 1;58(1):222-34. doi: 10.1002/prot.20275
- J Mol Graph Model. 2004 Dec;23(3):223-31. doi: 10.1016/j.jmgm.2004.07.002.
Book Chapters
- Zhong HA. ADMET Properties: Overview and Current Topics. Chapter 8, Pages 113-133. Book, Drug Design: Principles and Applications. Editor, Abhinav Grover, Publisher: Springer Nature; 2017. ISBN 978-981-10-5187-6. DOI 10.1007/978-981-10-5187-6_8.
- Zhong HA, Güner OF, Bowen JP. Book Chapter, Chapter 20, "Rational Drug Discovery, Design, and Development" (pages 443-464), in Book titled Drug Delivery: Fundamentals and Applications, Second Edition ISBN 9781482217711 - CAT# K22118, CRC Press, Editors: Anya M Hillery, Kinam Park. (2016)
- Zhong HZ, and Bowen JP. Computer-assisted drug design. Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition DOI: 10.1081/E-EPT4-120050222. July, 2013. Pages, 620-633. Informa plc (Switzerland)
- Bowen JP and Zhong HZ. Computational Chemistry. Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition DOI: 10.1081/E-EPT4-120050220. July, 2013, Pages, 600-614. Informa plc (Switzerland)
- Zhong HZ, Lee M, Bowen JP, “Modeling and Simulations of Nucleic Acids and Their Complexes”. In Book "Synthetic and Biophysical Studies of DNA Binding Compounds." Editors: Moses Lee and Lucjan Strekowski, ISBN: 978-81-7895-290-1. Transworld Research Network, Kerala, India (2007: pages 93-129).
Additional Information
Awards and Honors
Excellence in Research/Creative Activity Award, College of Arts and Sciences, University of Nebraska at 51社区, (2020).
The Cottrell College Science Award, Research Corporation (2008)
Editorial Service:
Editorial Board, Journal of Molecular Graphics & Modelling (2020-present)
Associate Editor, Journal of Molecular Graphics & Modelling (2024-present)
Review Board Member, Cancers (2020-present)
Guest Editor, Special Issue: Structure-based Design on Anticancer Drug Discovery. Current Topics in Medicinal Chemistry, 2020, Vol. 20, Issue 10.
Co-Guest Editor (with Guest Editor, J. Phillip Bowen), Special Issue: Advances in Drug Discovery for the Treatment of Cancer: Many Approaches, One Goal, Current Topics in Medicinal Chemistry, 2016, Vol. 16 (13).
Guest Editor, Special Issue: ADME and Toxicity in Early Drug Discovery, Current Topics in Medicinal Chemistry, 2013, Vol. 13 (11).
Publications
For a complete publication list. please . (Google Scholar h-index: 27)
- Expert Opinion on Therapeutic Patents, 2024, 34(3), 141-158. DOI:
- , Expert Opinion on Therapeutic Patents, 2024, 34(1-2), 51-69, DOI: HA.*
- Zhong, H.A.*; Goodwin, D.T. . Molecules 2024, 29, 1233. https://doi.org/10.3390/molecules29061233
- Hamilton LJ, Pattabiraman M, Zhong HA, Walker M, Vaughn H, Chandra S. . Pharmaceuticals. 2023, 16(7), 917; https://doi.org/10.3390/ph16070917.
- J. Mol. Graphics & Modeling., 2023, 121, 108433.
- Bioorg Med Chem. 2021, 46:116368 . https://doi.org/10.1016/j.bmc.2021.116368
- Dima A. Sabbah, Rima Hajjo, Sanaa K. Bardaweel & Haizhen A. Zhong.* , Expert Opinion on Therapeutic Patents, 2021, 31:10, 877-892, DOI:
10.1080/13543776.2021.1924150. - Sabbah DA, Hajjo R, Bardaweel SK, Zhong HA. . Curr Top Med Chem. 2021;21(7):571-596. doi: 10.2174/1568026621666210119111409. PMID: 33463470.
- Hamilton LJ, Walker M, Pattabiraman M, Zhong HA, Luedtke B, Chandra S. . Pharmacol Res. 2021 Mar;165:105410. doi: 10.1016/j.phrs.2020.105410. Epub 2021 Jan 2. PMID: 33401004.
- Sabbah DA, Hajjo R, Bardaweel SK, Zhong HA. . Curr Top Med Chem. 2021; 21(6):442-460. doi: 10.2174/1568026620666201207095117. PMID: 33292134.
- Sabbah DA, Hajjo R, Sweidan K, Zhong HA. . Curr Comput Aided Drug Des. 2020 Aug 19. doi: 10.2174/1573409916666200819113444. Epub ahead of print. PMID: 32814537.
- Curr Top Med Chem. 2020; 20 (10) :813-814. doi: 10.2174/156802662010200331100200. PubMed PMID: 32463006.
- Assay Drug Dev Technol. 2020 Apr; 18 (3) :109-118. doi: 10.1089/adt.2019.965. PubMed PMID: 32319818.
- Bioorg Med Chem. 2020 Apr 1; 28 (7) :115395. doi: 10.1016/j.bmc.2020.115395. Epub 2020 Feb 18. PubMed PMID: 32113844
- Almahmoud S, Zhong HA. . Int. J. Mol. Sci., 2019, 20, 4654. doi:10.3390/ijms20184654.
- Daszynski DM, Santhoshkumar P, Phadte AS, Sharma KK, Zhong HA, Lou MF, Kador PF. . Sci Rep. 2019 Jun 11; 9(1):8459. doi: 10.1038/s41598-019-44676-4.
- Almahmoud S, Wang X, Vennerstrom JL, Zhong HA*. . Molecules. 2019 Jun 7;24(11). pii: E2159. doi: 10.3390/molecules24112159.
- Sabbah DA, Ibrahim AH, Talib WH, Alqaisi KM, Sweidan K, Bardaweel SK, Sheikha GA, Zhong HA, Al-Shalabi E, Khalaf RA, Mubarak MS. . Med Chem. 2019, 15, 417-429. doi: 10.2174/1573406414666180912111846.
- Zhong HA, Santos EM, Vasileiou C, Zheng Z, Geiger JH, Borhan B, Merz KM Jr. . J Am Chem Soc. 2018 Mar 14;140(10):3483-3486. doi: 10.1021/jacs.7b10368. Epub 2018 Feb 28..
- Xianting Cao, Haizhen A. Zhong, Pengfei Zhang, and Hui Zheng. . Journal of CO2 Utilization, 2018, 24, 250-255.
- Sabbah DA, Al-Tarawneh F, Talib W, Sweidan K, Bardaweel S, Al-Shalabi E, Zhong HA, Abu Sheikha G, Abu Khalaf R, Mubarak MS. . Medicinal Chemistry. 2018, 14 (7), 695-708; doi: 10.2174/1573406414666180412160142.
- Sabbah DA, Hishmah B, Sweidan K, Bardaweel S, AlDamen M, Zhong HA, Abu Khalaf R, Ibrahim AH, Al-Qirim T, Abu Sheikha G, Mubarak MS. . Anticancer Agents Med Chem. 2018, 18(2), 263-276. doi: 10.2174/1871520617666170911171152.
- Kumar V, Chaudhary AK, Dong Y, Zhong HA, Mondal G, Lin F, Kumar V, Mahato RI. . Sci Rep. 2017 May 10; 7(1):1665. doi: 10.1038/s41598-017-01942-7.
- Udumula V, Endres JL, Harper CN, Jaramillo L, Zhong HA, Bayles KW, Conda-Sheridan M. . Eur J Med Chem. 2017, 125:710-721. doi: 10.1016/j.ejmech.2016.09.079. Epub 2016 Sep 28.
- Sabbah DA, and Zhong HA. . J. Mol. Graphics & Modeling., 2016, 68, 206-215
- Sabbah DA, Hu J, Zhong HA. . Curr. Top. Med. Chem., 2016, 16, 1413-26.
- Xu D, Li R, Wu J, Jiang L, Zhong HA. . Curr. Top. Med. Chem., 2016, 16, 1441-51.
- Ehlers T, Furness S, Robinson TP, Zhong HA, Goldsmith D, Arbiser J, Bowen JP. . Curr. Top. Med. Chem. , 2016, 16 (13), 1478-88.
- Curr Top Med Chem. 2016;16(13):1411-2. doi: 10.2174/1568026616999151012120106.
- Curr Top Med Chem. 2016;16(9):897-8. doi: 10.2174/1568026616999151029114013.
- Infect Genet Evol. 2014 Mar;22:192-200. doi: 10.1016/j.meegid.2013.10.011.
- Curr Top Med Chem. 2013;13(11):1255-6. doi: 10.2174/15680266113139990031
- Curr Pharm Des. 2013;19(26):4701-13. doi: 10.2174/1381612811319260004.
- Synthesis and self-assembly of triphenylene-containing conjugated macrocycles. RSC advances. 2013; 3:6008. doi: DOI: 10.1039/C3RA23421E.
- Curr Top Med Chem. 2013;13(11):1290-307. doi: 10.2174/15680266113139990034.
- J Chem Inf Model. 2012 Dec 21;52(12):3213-24. doi: 10.1021/ci3003057.
- Bioorg Med Chem. 2012 Dec 15;20(24):7175-83. doi: 10.1016/j.bmc.2012.09.059.
- PLoS One. 2012;7(7):e38665. doi: 10.1371/journal.pone.0038665
- Bioorg Med Chem Lett. 2012 Jan 15;22(2):876-80. doi: 10.1016/j.bmcl.2011.12.044.
- Int J Bioinform Res Appl. 2012;8(1-2):81-98. doi: 10.1504/IJBRA.2012.045978.
- Synthesis and optical properties of perylene diimide derivatives with triphenylene-based dendrons linked at the bay positions through a conjugated ethynyl linkage. Tetrahedron. 2012; 68(13):2806. doi: .
- ACS Med Chem Lett. 2011 Jun 9;2(6):455-60. doi: 10.1021/ml200031m.
- J Phys Chem A. 2011 Mar 10;115(9):1579-92. doi: 10.1021/jp1085334.
- Curr Top Med Chem. 2011;11(12):1571-90. doi: 10.2174/156802611795860924
- Curr Med Chem. 2011;18(36):5528-44. doi: 10.2174/092986711798347298.
- J Chem Inf Model. 2010 Oct 25;50(10):1887-98. doi: 10.1021/ci1002679.
- J Mol Graph Model. 2009 Nov;28(4):336-46. doi: 10.1016/j.jmgm.2009.08.012.
- Bioorg Med Chem Lett. 2008 Jan 15;18(2):542-5. doi: 10.1016/j.bmcl.2007.11.090
- J Am Chem Soc. 2007 Oct 24;129(42):12809-14. doi: 10.1021/ja073687x.
- Galahad, Tripos Inc. (Computer Software Review). J. Am. Chem. Soc.. 2007; 129:5780. doi: DOI: 10.1021/ja069815j
- Curr Top Med Chem. 2007;7(14):1379-93. doi: 10.2174/156802607781696855.
- J Chem Theory Comput. 2006 Mar;2(2):342-53. doi: 10.1021/ct050182t
- Curr Med Chem. 2006;13(8):849-62. doi: 10.2174/092986706776361085
- J Mol Graph Model. 2005 Sep;24(1):1-9. doi: 10.1016/j.jmgm.2005.04.003
- J Chem Theory Comput. 2005 Mar;1(2):230-8. doi: 10.1021/ct049890p
- Proteins. 2005 Jan 1;58(1):222-34. doi: 10.1002/prot.20275
- J Mol Graph Model. 2004 Dec;23(3):223-31. doi: 10.1016/j.jmgm.2004.07.002.
Book Chapters
- Zhong HA. ADMET Properties: Overview and Current Topics. Chapter 8, Pages 113-133. Book, Drug Design: Principles and Applications. Editor, Abhinav Grover, Publisher: Springer Nature; 2017. ISBN 978-981-10-5187-6. DOI 10.1007/978-981-10-5187-6_8.
- Zhong HA, Güner OF, Bowen JP. Book Chapter, Chapter 20, "Rational Drug Discovery, Design, and Development" (pages 443-464), in Book titled Drug Delivery: Fundamentals and Applications, Second Edition ISBN 9781482217711 - CAT# K22118, CRC Press, Editors: Anya M Hillery, Kinam Park. (2016)
- Zhong HZ, and Bowen JP. Computer-assisted drug design. Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition DOI: 10.1081/E-EPT4-120050222. July, 2013. Pages, 620-633. Informa plc (Switzerland)
- Bowen JP and Zhong HZ. Computational Chemistry. Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition DOI: 10.1081/E-EPT4-120050220. July, 2013, Pages, 600-614. Informa plc (Switzerland)
- Zhong HZ, Lee M, Bowen JP, “Modeling and Simulations of Nucleic Acids and Their Complexes”. In Book "Synthetic and Biophysical Studies of DNA Binding Compounds." Editors: Moses Lee and Lucjan Strekowski, ISBN: 978-81-7895-290-1. Transworld Research Network, Kerala, India (2007: pages 93-129).